Fooling a protein into folding

Much like a ball of yarn is expertly knitted into a beautiful sweater, a long chain of amino acids folds into a particular shape and becomes a functioning protein. Except, a protein is able to do that all by itself, without any knitter, through a process known as ‘protein folding’. Understanding folding and gaining the ability to control it can get us one step closer to understanding how life works, and to modulate it as per our wish.

The TIFR team lead by Prof. Sudipta Maiti and Prof. ASR Koti have now demonstrated that a small designed Xeno-nucleus peptide can selectively catalyze folding of a target protein. These results have now been published in the Journal of the American Chemical Society

Click to view the file

https://doi.org/10.1021/jacs.1c09611